品牌:卡梅德生物科技(天津)有限公司
发货:3天内
信息标签:重组人类anti-COVID-19/SARS-CoV-2 S1 RBD单克隆抗体,供应,医药与器械,生物制品
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产品编号 | MAV102 |
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产品名称 | Recombinant Human anti-COVID-19/SARS-CoV-2 S1 RBD Monoclonal Antibody |
抗体亚型 | IgG1 |
克隆号 | 7H6 |
规格与价格 | 100ul/¥2,300; 500ul/¥6,500; 1000ul/¥11,000 |
产品别称 | SARS-CoV-2 RBD antibody, 2019-nCoV, Coronavirus |
规格 | 100ul/¥2,300 |
物种 | COVID-19 |
宿主 | Human |
产品应用 | ELISA, Colloidal Gold, POCT, Neutralizaiton , Standard Positive Control |
内毒素水平 | <0.1EU/ug determided by LAL method. |
交叉反应 | React with SARS-CoV-2(COVID-19) S1-RBD protein. Do not react with other SARS-CoV-2 subunits. |
缓冲体系 | 0.01M PBS, pH 7.4 |
免疫原 | Native virus |
产品背景 | A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) recently emerged and is rapidly spreading in humans, causing COVID-19. A key to tackling this pandemic is to understand the receptor recognition mechanism of the virus, which regulates its infectivity, pathogenesis and host range. SARS-CoV-2 and SARS-CoV recognize the same receptor—angiotensin-converting enzyme 2 (ACE2)—in humans. Researchers determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 (engineered to facilitate crystallization) in complex with ACE2. In comparison with the SARS-CoV RBD, an ACE2-binding ridge in SARS-CoV-2 RBD has a more compact conformation; moreover, several residue changes in the SARS-CoV-2 RBD stabilize two virus-binding hotspots at the RBD–ACE2 interface. These structural features of SARS-CoV-2 RBD increase its ACE2-binding affinity. Additionally, we show that RaTG13, a bat coronavirus that is closely related to SARS-CoV-2, also uses human ACE2 as its receptor. |
保存条件 | This product can be stored at 2℃-8℃ for one month. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
备注 | This product is used for research use only. Not for human or diagnostic use. |